All Articles Tagged As: tissue engineering

Novel hydrogel systems for dentin regeneration (7/7/2008)

Preliminary data describes the results of studies on hydrogels made of peptide amphiphiles, where a short peptide sequence is attached to a fatty acid, which provides the driving force for self-assembly ...> Full Article

Gene directs stem cells to build the heart (7/5/2008)

Researchers have shown that they can put mouse embryonic stem cells to work building the heart, potentially moving medical science a significant step closer to a new generation of heart disease treatments that use human stem cells. ...> Full Article

Researchers Find Key Developmental Pathway Activates Lung Stem Cells (6/20/2008)

Pathway Could Hold Promise for Lung Tissue Repair ...> Full Article

Cartilage regeneration '20,000 Leagues Under the Sea' (6/8/2008)

Engineers use high pressure to stimulate growth of new cartilage ...> Full Article

Saving teeth by using periodontal ligament regeneration (6/6/2008)

3D in vitro model appears to be promising for regenerating periodontal ligament and may also prove valuable for restoring tendons and ligaments elsewhere in the body. ...> Full Article

DOD Funds Massive Project Directed at Battlefield Injuries (4/21/2008)

Project will be dedicated to repairing battlefield injuries through the use of regenerative medicine, science that takes advantage of the body's natural healing powers to restore or replace damaged tissue and organs. ...> Full Article

Cardiff stem cell expertise showcases at national conference (4/12/2008)

Cardiff University research will be showcased at an annual scientific conference celebrating the latest and best in UK stem cell science ...> Full Article

Researchers Engineer First System of Human Nerve-Cell Tissue (3/31/2008)

Implications for Nerve Repair and Implantation ...> Full Article

Researchers control growth rate of replacement blood vessels, tissues (3/9/2008)

Researchers have discovered a way to control the growth rate of replacement tissue and the formation of new blood vessels, which solves one of the vexing problems of growing replacement tissue to treat injuries and trauma in humans. ...> Full Article

Scientists Testing Stem Cell Treatment on Injured Horses (2/22/2008)

Researchers at the Ontario Veterinary College (OVC) are offering stem cell therapy to repair injured tendons and ligaments in horses with the aim of researching the possibility of similar treatment in humans. ...> Full Article

Adult Stem Cells Beneficial in Heart Failure Recovery (1/26/2008)

A study in the Clinical and Experimental Pharmacology and Physiology published by Wiley-Blackwell shows that administration of adult bone marrow stem cells (BMC) and mesenchymal stems cells (MSC) can aid in the recovery of myocardial infarction (MI) - commonly known as heart attack - and consequently increase survival rates. ...> Full Article

Study Reports Successful Cloning of Human Embryo Using Adult DNA (1/18/2008)

Key Step Toward Developing Embryonic Stem Cell Lines for Therapeutic Cloning ...> Full Article

Researchers identify mechanism that controls activation of stem cells during hair regeneration (1/17/2008)

Researchers at the University of Southern California have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature. ...> Full Article

Beating Heart Created In Laboratory: Method May Revolutionize How Organ Tissues Are Developed (1/15/2008)

University of Minnesota researchers have created a beating heart in the laboratory. ...> Full Article

Protein in Human Hair Shows Promise for Regenerating Nerves (1/11/2008)

A protein found in human hair shows promise for promoting the regeneration of nerve tissue and could lead to a new treatment option when nerves are cut or crushed from trauma. ...> Full Article

Mechanism by which Signaling Pathways Regulate Growth and Differentiation of Adult Muscle Stem Cells is Revealed (1/8/2008)

During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue. Although the signaling pathways controlling muscle regeneration are fairly well known, how these signals lead to altered chromatin structure remains undiscovered. A group of scientists at the Burnham Institute for Medical Research in La Jolla, CA, analyzed the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative microenvironment, thus controlling the expression of genes that regulate growth and differentiation of muscle stem cells that repair injured muscle. ...> Full Article

Growing Artificial Skin From Hair Roots (1/5/2008)

There is new hope for patients with chronic wounds: euroderm GmbH and the Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig have been granted approval to produce artificial skin from patients' own cells. ...> Full Article

Researcher orks toward engineered blood vessels (12/19/2007)

Vessels could be used in human body ...> Full Article

Gene regulates polarity in flatworms (12/9/2007)

When cut, a planarian flatworm can use a population of stem cells called neoblasts to regenerate new heads, new tails or even entire new organisms from a tiny fragment of its body. Mechanisms have been sought to explain this process of regeneration polarity for over 100 years, but until now, little was known about how planaria can regenerate heads and tails at their proper sites. ...> Full Article

Sculpted 3-D particles could aid diagnostics, tissue engineering (12/5/2007)

Engineers have used ultraviolet light to sculpt three-dimensional microparticles that could have many applications in medical diagnostics and tissue engineering. For example, the particles could be designed to act as probes to detect certain molecules, such as DNA, or to release drugs or nutrients. ...> Full Article

Enzyme Mutation Disrupts Organ Growth (11/29/2007)

The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting. A key player in the process--called transcription--is the enzyme RNA polymerase III. A new study reports that a mutation of this enzyme prevents cell division, but surprisingly, only affects the development of specific organs. It may also have a therapeutic application against cancer. ...> Full Article

'Micro' livers could aid drug screening (11/24/2007)

Researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development. ...> Full Article

Engineered Skin Spurs Natural Healing (11/22/2007)

A team of Chinese doctors reported in a recent issue of Artificial Organs that skin they developed from neonatal foreskin heals wounds quickly and with minimal scarring. ...> Full Article

Hemoglobin's secrets uncovered could lead to better blood (11/8/2007)

Researchers have unveiled crucial information about the protein transporter of oxygen, which opens up the possibility to optimize its function by introducing modifications. ...> Full Article

Research Team Makes Progress Toward 'Printing' Organs (11/7/2007)

Biology-based process maintains cell properties and lets nature do the rest ...> Full Article

Researchers find signal that switches on eye development - Could lead to 'eye in a dish' (10/26/2007)

A British research team discovered signal that triggers eye development. ...> Full Article

Stem cells may enhance capability of heart cells to regenerate (10/12/2007)

During a fatal heart attack, at least 1 billion heart cells are killed in the left ventricle, one of the heart's two big lower pumping chambers that move blood into the body. ...> Full Article

Scientists repair heart attacks with engineered tissue (10/10/2007)

Research shows that it may be possible to one day repair a person's heart after a heart attack by using a "patch" grown from his or her own cells. ...> Full Article

Microchannels for tissue growth (10/9/2007)

laboratories may grow synthetically engineered tissues such as muscle or cartilage needed for transplants. In a major step forward ...> Full Article

Cilia key to cell signalling that tells a cell what type of cell to become (10/4/2007)

Researchers say they have figured out how human and all animal cells tune in to a key signal, one that literally transmits the instructions that shape their final bodies. It turns out the cells assemble their own little radio antenna on their surfaces to help them relay the proper signal to the developmental proteins "listening" on the inside of the cell. ...> Full Article

Cell growth technology promises more successful drug development (9/22/2007)

Scientists have developed unique technology to grow stem cells and other tissue in the laboratory in conditions similar to the way they grow in the human body. ...> Full Article

Stem Cells Derived from Adult Testes Produce Wide Range of Tissue Types for Therapeutic Organ Regeneration (9/20/2007)

After a decade of research, Howard Hughes Medical Institute scientists have succeeded in reprogramming adult stem cells from the testes of male mice into functional blood vessels and contractile cardiac tissue. The research offers a promising new source of stem cells for use in organ regeneration studies. ...> Full Article

World experts attend opening of new UK stem cell and regenerative medicine research centre (9/18/2007)

The new Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM) will be officially opened at the University of Nottingham on the 21st September, 2007 by Sir Keith O'Nions, Director General Science and Innovation at the Department for Innovation, Universities and Skills. ...> Full Article

Scientists Eye Secrets of Retinal Regeneration (9/15/2007)

Peering at microscopic changes within the retina, scientists in the Department of Ophthalmology at Weill Cornell Medical College in New York City, have discovered a key mechanism driving eye health and eye disease. ...> Full Article

Researcher IDs Regenerative Cells in Tendons (9/12/2007)

USC School of Dentistry researcher's findings promise new treatments for tendon injury and disease. ...> Full Article

Embryonic stem cells used to grow cartilage (9/7/2007)

Method is first to yield cartilage-like cells, engineer human cartilage ...> Full Article

Building Muscle Requires Foxo1 (8/26/2007)

The mechanisms by which Foxo proteins regulate metabolism are relatively well characterized. However, little was known about the mechanisms by which these same proteins regulate cellular differentiation. ...> Full Article

Researchers Turn Mouse into Factory for Human Liver Cells (8/11/2007)

A new company is spun off to market technology that could become a drug testing standard ...> Full Article

Tissue-Engineering Research Focuses On Vocal Cords (8/1/2007)

Damaged or diseased vocal cords can forever change and even silence the voices we love, from a family member's to a famous personality's. ...> Full Article

Scientists Invent Novel Hydrogels For Repairing And Regenerating Human Tissue (7/21/2007)

University of Delaware scientists have invented a novel biomaterial with surprising antibacterial properties that can be injected as a low-viscosity gel into a wound where it rigidifies nearly on contact - opening the door to the possibility of delivering a targeted payload of cells and antibiotics to repair the damaged tissue. ...> Full Article

Can Heart Tissue Be Regenerated? (7/19/2007)

Mature heart cells, given the right environment, can replicate ...> Full Article

Team Finds New Mechanism Of Gene Control (7/15/2007)

Further understanding might aid regenerative medicine, more ...> Full Article

When Tissue Repair Backfires (7/9/2007)

A new molecular link between inflammation and cancer, discovered through experiments with mice, has revealed how the body's natural repair response to tissue injury can actually spur tumor growth. ...> Full Article

Engineered Blood Vessels Function like Native Tissue (7/8/2007)

Blood vessels that have been tissue-engineered from bone marrow adult stem cells may in the future serve as a patient's own source of new blood vessels following a coronary bypass or other procedures that require vessel replacement, according to new research from the University at Buffalo Department of Chemical and Biological Engineering. ...> Full Article

Researchers Use Adult Stem Cells to Create Soft Tissue (7/7/2007)

Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient's own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents. ...> Full Article

New Method For Reading DNA Sheds Light On How Cells Define Themselves (7/6/2007)

As a fertilized egg develops into a full-grown adult, mammalian cells make many crucial decisions - closing doors of opportunity as they adopt careers as liver cells, skin cells, and even neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. ...> Full Article

Scientists Discover How Cells Decide What Type Of Tissue To Become (7/4/2007)

As a fertilized egg develops into a full-grown adult, mammalian cells adopt careers as different cell types, from liver cells to neurons. One of the most fundamental mysteries in biomedicine is how cells make such different career decisions despite having exactly the same DNA. ...> Full Article

Tissue Engineered Scaffolding Allows Reproduction of Cartilage Tissue (5/11/2007)

A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. ...> Full Article

Key Player In Embryonic Muscle Development (4/15/2007)

In the future, this finding may help in designing new methods for healing injured and diseased muscle tissue using stem cells ...> Full Article

Liver Regeneration May Be Simpler Than Previously Thought (4/14/2007)

The way the liver renews itself may be simpler than what scientists had been assuming. A new study, appearing in the April 13 issue of The Journal of Biological Chemistry, provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver diseases such as cirrhosis, hepatitis, or cancer. ...> Full Article

Researchers Engineer Tissues To Reduce Use Of Animals In Research (4/11/2007)

Colorado State University is engineering tissue in a laboratory that can replace the use of animals in research. The Tissue Engineering Laboratory, established this academic year in the College of Veterinary Medicine and Biomedical Sciences, creates tissue from a combination of cells, materials and biochemicals that model living biological systems. The model tissue replaces live animals in the initial phases of many biological studies, reducing the number of animals needed for use in research. ...> Full Article

Female Stem Cells Work Better, According To New Study (4/9/2007)

Female stem cells derived from muscle have a greater ability to regenerate skeletal muscle tissue than male cells, according to a study at Children's Hospital of Pittsburgh of UPMC. ...> Full Article

Engineering the heart piece by piece (4/1/2007)

U-M scientists see great promise in cardiac tissue engineering, but hurdles remain before lab-grown muscle is ready for patients ...> Full Article

Stem Cells Speed Growth Of Healthy Liver Tissue (3/31/2007)

For the first time, researchers have used adult bone marrow stem cells to regenerate healthy human liver tissue, according to a study published in the April issue of the journal Radiology. ...> Full Article

Intelligent materials to regenerate bone tissue (3/30/2007)

Scientists working on the regeneration and repair of bone tissue by developing a support matrix out of a compound that is intelligent. ...> Full Article

Scientists Progress In Successful Tissue Engineering (3/26/2007)

Tissue engineering is a relatively new field of basic and clinical science that is concerned, in part, with creating tissues that can augment or replace injured, defective, or diseased body parts. The approach to fabricating the tissues involves adding specific cell types to grow on a polymer scaffold having the shape of the tissue to be restored. The scaffold gradually disappears, while the cells continue developing in the scaffold shape. With the use of non-human animal cells, there has been considerable recent progress made in the engineering of skin, bladder, cartilage, and several other tissues. ...> Full Article

Scientists Re-grow Dental Enamel From Cultured Cells (3/26/2007)

Dental enamel is the hardest tissue produced by the body. It cannot regenerate itself, because it is formed by a layer of cells that is lost by the time the tooth appears in the mouth. The enamel spends the remainder of its lifetime vulnerable to wear, damage, and decay. ...> Full Article

Reconstructing an aging eye with Stem cells (3/20/2007)

Due to damage from injuries or disease, the ability of the eyes to produce replacement corneal epithelial cells may be impaired. The cornea becomes cloudy, the vision deteriorates and the patient experiences considerable discomfort. A new technique is being test to replace the stem cells in the eye, so that it can continue to regenerate. ...> Full Article

Building bone marrow with Stem Cells (3/20/2007)

A team of researchers from the University of Minnesota and Stanford University has found that a type of adult stem cell can replace the bone marrow and regenerate the immune systems of mice. If the finding can be extended to humans, it could mean a new and more abundant supply of cells for bone marrow transplant patients. ...> Full Article

Growing Eyes on Biomimetic Scaffolds (3/10/2007)

New sight for those who are blinded by macular degeneration may be moving closer to the list of medical miracles. In the young field of regenerative medicine, a UCSF scientist has invented unique microscopic scaffolds to support the growth of new cells to replace those lost to disease. ...> Full Article

Scientists grow lung epithelial cells for transplants (3/5/2007)

Molecular scientists at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM) – which is part of the University of Texas Health Science Center at Houston – have developed a new procedure for the differentiation of human embryonic stem cells, with which they have created the first transplantable source of lung epithelial cells. ...> Full Article

Scientists re-grow tadpole tail hoping to learn how to regenerate limbs in humans (3/2/2007)

Scientists at the Forsyth Institute may have moved one step closer to regenerating human spinal cord tissue by artificially inducing a frog tadpole to re-grow its tail at a stage in its development when it is normally impossible. ...> Full Article

Bioengineer advances survival and promise of adult stem cells (3/1/2007)

MIT researchers have developed a technique to encourage the survival and growth of adult stem cells, a step that could help realize the therapeutic potential of such cells. ...> Full Article

Liposuctioned fat stem cells to repair bodies (2/28/2007)

Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body. A team led by Philippe Collas at the University of Oslo in Norway has identified certain chemical marks that allow him to predict which, among the hundreds of millions of stem cells in liposuctioned fat, are best at regenerating tissue. ...> Full Article

Woven Scaffolds Could Improve Cartilage Repair (2/27/2007)

Using a unique weaving machine of their design, Duke University Medical Center researchers have created a three-dimensional fabric "scaffold" that could greatly improve the ability of physicians to repair damaged joints with the patient's own stem cells. ...> Full Article

Human stem cell transplants repair rat spinal cords (2/23/2007)

Human nerve stem cells transplanted into rats’ damaged spinal cords have survived, grown and in some cases connected with the rats’ own spinal cord cells in a Johns Hopkins laboratory, overturning the long-held notion that spinal cords won’t allow nerve repair. ...> Full Article

Researchers use stem cells to create living dental implants (1/23/2007)

USC School of Dentistry researcher Songtao Shi, DDS, PhD, has regenerated tooth root and supporting periodontal ligaments to restore tooth function in 4–8 month-old pigs. ...> Full Article

Tengion begins phase II clinical trial of regenerated human organ (1/16/2007)

Tengion, Inc of East Norriton, PA has announced that it has launched phase II multi-center clinical study for its urinary neo-bladder construct. ...> Full Article

Advances in growing new teeth (1/16/2007)

Dr. Paul Sharpe, through his startup Odontis, has continued his research into growing teeth from dental stem cells and has learned to control the type of tooth formed. ...> Full Article

Cell therapy for cartilage repair (1/11/2007)

PhD student Jeanine Hendriks of University of Twente’s Institute for Biomedical Technology has developed a better method of growing cartilage. ...> Full Article

UK Scientists to grow heart arteries (1/8/2007)

Andrew Owens of Durham University and James Cook University Hospital on Teesside have received a £84,000 grant from Heart Research UK to try and "grow" test tube arteries for use in heart bypass operations. ...> Full Article

Genetically Modified Skin Cells May Help Burn Victims Fight Infection (1/8/2007)

Dorothy Supp, PhD and her team at the University of Cincinnati have created genetically altered skin cells that, may help fight off potentially lethal infections in patients with severe burns. ...> Full Article

Bioprinter grows multiple tissues at one time (12/12/2006)

Julie Phillippi at Carnegie Mellon University in Pennsylvania has created a bio-ink printer that can print muscle-derived stem cells onto bio-paper and can have them turn into either muscle or bone. ...> Full Article

Human Heart Valves Grown Using Stem Cells (11/21/2006)

Dr. Simon Hoerstrup of the University of Zurich has announced that he and his team have developed a method for growing new heart valves in a laboratory. ...> Full Article

Liver Grown From Stem Cells (10/31/2006)

Scientists at Newcastle University, in the UK, grew a miniature liver, using stem cells taken from umbilical cords. ...> Full Article

Repairing Broken Hearts With Stem Cells (9/25/2006)

Dr. Andreas M. Zeiher is the chair of the Department of Medicine at Johann Wolfgang Goethe University in Frankfurt and senior author of a study that has infused stem cells onto a damaged hearts. The stem cells, harvested from the patients' own bone marrow, were then injected onto the heart in a single operation. The operation was performed on several patients who had suffered a heart attack months, years, and even decades before. ...> Full Article

Rejuvenating Heart Tissue (9/6/2006)

Phase one clinical trials for a procedure to rejuvenate damaged heart tissue have begun. ...> Full Article

Silk used to grow nerves (7/14/2006)

Researchers at Queen Mary's School of Medicine and Dentistry in London have developed a silk like fibre that can be used to grow nerve cells on. The silk, called Spidrex, comes from modified silk worms. The modified silk allows cells to bind to it easily. ...> Full Article

Cloned Knee Cartilage (7/5/2006)

Scientists led by Antony Hollander, ARC Professor of Rheumatology & Tissue Engineering at Bristol University in South West England have successfully grown and implanted knee cartilage into 23 patients. The process started by removing health cartilage from 23 patients. The cartilage is then grown for 14 days in a culture. The researchers then deposited the cartilage cells onto a esterified hyaluronic acid scaffold. They were grown on the scaffold for another 14 days. ...> Full Article

Printing New Tissues (4/14/2006)

Researchers at University of Missouri in Columbia, have demonstrated a new device that prints different types of tissues such as heart muscle onto biopaper. ...> Full Article

Human kidney cloned in rats (2/22/2005)

Researchers in Japan claim they've cloned a human kidney by harvesting human stem cells taken from adult bone marrow into rat embryos. ...> Full Article

Stem Cells To Repair Eyes (9/26/2004)

Researchers at Advanced Cell Technology in Massachusetts have coaxed stem cells into becoming retinal cells. They used stem cells taking from human embryos created by a team at Harvard University. Dr. Robert Lanza, Advanced Cell Technology’s scientific director and his team were intrigued when the cells began to cluster into small globes that looked like little eyes. The technology is still several years away, but can offer hope to those suffering from degenerative retinal problems. ...> Full Article

Growing new teeth (2/17/2004)

Professor Paul Sharpe, who is the director of the craniofacial department at the Dental Institue in King's College London says researchers can grow fully formed adult teeth in mice. The technique, similar to those used by Forsyth Institute researchers, uses the subjects own dental stem cells. The stem cells are then combined with embryonic epithelium, and are placed into the kidneys of the mice, which provide a good supply of blood and oxygen for the tooth to develop. The tooth is then removed from the kidney and is transplanted into the mouth. The tooth, which is still small, then grows into a normal tooth attaching to the underlying bone. ...> Full Article

Tissue Engineering Tooth Crowns (9/26/2002)

Researchers at The Forsyth Institute have successfully used tissue engineering techniques to regenerate mammalian tooth crowns containing dentin and enamel—a feat that could, one day, lead to a biological tooth substitute to replace lost or missing human teeth. The research also suggests the existence of dental stem cells—which could be key to bioengineering human teeth. ...> Full Article

Cloned kidney transplant in cattle (6/6/2002)

Researchers with Tissue Engineering at Children's Hospital Bostonwho transplanted cloned cattle cells that formed working mini-kidneys say their experiment shows the potential of cloning replacement tissues and organs. ...> Full Article