Cloning and Regenerative Medicine News
 | A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer. ...> Full Article |
Melissa Knothe Tate, of Case Western Reserve University, and Ulf Knothe, of the Cleveland Clinic, have shown that the stem-cell rich periosteum sheath around bone can be used to mend serious bone loss faster and more simply than bone grafts. The pair has developed an artificial periosteum that can be implanted in patients who have too little of the natural covering left.
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 | Scientists at the Stanford University School of Medicine have devised a software algorithm that could enable a common laboratory device to virtually separate a whole-blood sample into its different cell types and detect medically important gene-activity changes specific to any one of those cell types. ...> Full Article |
 | Mice are in many ways similar to Homo sapiens on a fundamental level. That is why the law in this part of the world only permits scientists to conduct research on human embryonic stem cells when they have "clarified in advance" their specific questions by using animal cells as far as possible. However, such tests are often pointless -- and sometimes even misleading, as a recent study by scientists at the Max Planck Institute for Molecular Biomedicine in Munster, Germany, demonstrates. ...> Full Article |
In a leap toward making stem cell therapy widely available, researchers have discovered that endothelial cells, the most basic building blocks of the vascular system, produce growth factors that can grow copious amounts of adult stem cells and their progeny over the course of weeks. Until now, adult stem cell cultures would die within four or five days despite best efforts to grow them.
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Components of the blood or hematopoietic system derive from stem cell subtypes rather than one single stem cell that gives rise to all the different kinds of blood cells equally, said scientists from Baylor College of Medicine in a report that appears in the current issue of the journal Cell Stem Cell.
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 | Researchers at Rensselaer Polytechnic Institute have discovered a new method for predicting -- with up to 99 percent accuracy -- the fate of stem cells. Using advanced computer vision technology to detect subtle cell movements that are impossible to discern with the human eye, Professor Badri Roysam and former student Andrew Cohen can successfully forecast how a stem cell will split and what key characteristics the daughter cells will exhibit. ...> Full Article |
 | A heart patient's own skin cells soon could be used to repair damaged cardiac tissue thanks to pioneering stem cell research of the University of Houston's newest biomedical scientist, Robert Schwartz. His new technique for reprogramming human skin cells puts him at the forefront of a revolution in medicine that could one day lead to treatments for Alzheimer's, diabetes, muscular dystrophy and many other diseases. ...> Full Article |
Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research shows. This muscle-wasting disease results when a child's motor neurons -- nerve cells that send signals from the spinal cord to muscles -- produce insufficient amounts of what is called survival motor neuron protein, or SMN.
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Several genes affect tooth development in the first year of life, according to the findings of a study conducted at Imperial College London, the University of Bristol in the UK and the University of Oulu in Finland. The research, published Feb. 26 in the open-access journal PLoS Genetics, shows that the teeth of babies with certain genetic variants tend to appear later and that these children have a lower number of teeth by 1 year of age.
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Researchers at Rhode Island Hospital have discovered how cells communicate with each other during times of cellular injury. The findings shed new light on how the body repairs itself when organs become diseased, through small particles known as microvesicles, and offers hope for tissue regeneration. The paper is published in the March 2010 edition of the journal Experimental Hematology and is now available online in advance of publication.
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A spray-on skin product and an injectable cell therapy for heart attack patients are among 17 regenerative medicine technologies that will be showcased during the Translational Regenerative Medicine Forum, set for April 6-8 in Winston-Salem.
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 | An international research team led by Columbia University Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. This strategy could potentially become a new treatment for retinitis pigmentosa, a leading cause of blindness that affects approximately one in 3,000 to 4,000 people, or 1.5 million people worldwide. The study appears online ahead of print in the journal Transplantation. ...> Full Article |
Some 200 veterinarians, stem cell researchers and other medical professionals from throughout the United States and abroad will gather March 5-6 in the heart of California’s Central Coast horse region for a groundbreaking conference on the use of stem cell therapy and regenerative medicine to treat horses and other animals. This two-day working meeting will include scientific presentations, live demonstrations and discussion sessions.
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 | How do you study -- and try to cure in the laboratory -- an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. This "humanized" mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria. ...> Full Article |
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