Cloning and Regenerative Medicine News
Researchers at the Pontifícia Universidade Católica do Paraná and Instituto Carlos Chagas have evaluated the therapeutic potential of purified and expanded CD133+ cells human umbilical cord blood (HUCB)-derived in treating myocardial infarction by intramyocardially injecting them into a rat model. Patients who have high cardiovascular risks have fewer endothelial progenitor cells (EPCs) and their EPCs exhibit greater in vitro senescence. The results appear in the January 2010 issue of Experimental Biology and Medicine.
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 | Stem cell researchers exploring a new approach for the care of respiratory diseases report that an experimental treatment involving transplantable lung cells was associated with improved outcomes in tests on mice with acute lung injury. The lung cells were derived from human embryonic stem cells. Findings by investigators at the University of Texas Health Science Center at Houston are scheduled to appear in the March issue of Molecular Therapy. ...> Full Article |
 | Stem cell research at the University of California, Riverside will soon gather speed thanks to the establishment of a new Stem Cell Core Facility -- a shared facility providing infrastructure, equipment, and trained personnel for doing stem cell research. The SCCF is expected to produce breakthroughs at a much faster pace than before, assisted by its Nikon BioStation CT incubator. UCR is the first institution in the country to purchase the Nikon BioStation CT technology. ...> Full Article |
 | Northwestern University researchers are the first to design a bioactive nanomaterial that promotes the growth of new cartilage in vivo and without the use of expensive growth factors. The therapy is minimally invasive, utilizes bone marrow stem cells and produces natural cartilage. Unlike bone, cartilage does not grow back, and it cannot effectively be replaced. Countless people learn this all too well when they bring their bad knees, shoulders and elbows to an orthopedic surgeon. ...> Full Article |
Scientists at the Swedish medical university Karolinska Institutet have shown how transplanted stem cells can connect with and rescue threatened neurons and brain tissue. The results point the way to new possible treatments for brain damage and neurodegenerative diseases.
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Alternatives to liver transplantation are needed because of the shortage of liver donors. A research team in Taiwan has evaluated the transplantation of liver cells in animal models to assess efficacy. They found that enhanced proliferation of even small numbers of liver cells could reverse liver failure. Additionally, they found prolonged hepatic stellate cell activation, that is crucial for liver repair and plays a role in hepatocyte engraftment, which declined after four weeks.
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 | A natural material derived from crustacean shell and algae supports the growth of human embryonic stem cells. ...> Full Article |
Linheng Li, Ph.D., investigator, together with Hans Clevers, M.D., Ph.D., director of the Hubrecht Institute in Utrecht, Netherlands, co-authored a prospective review published today by the journal Science that proposes a model of mammalian adult stem cell regulation that may explain how the coexistence of two disparate stem cell states regulates both stem cell maintenance and simultaneously supports rapid tissue regeneration.
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In a major step toward commercialization of a promising therapeutic treatment, Oak Ridge National Laboratory contractor UT-Battelle has exclusively licensed patents on inventions based on the Nell-1 gene to NellOne Therapeutics, Inc. (NellOne), a company spun out of the Department of Energy laboratory.
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Using cells from mice, scientists discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. This strategy, described in a research report appearing the FASEB Journal, involves fusing bone marrow cells to embryonic stem cells. Once fused, hybrid cells have DNA from both donor and recipient, raising hopes that immune rejection of embryonic stem cell therapies can be avoided without drugs.
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The long struggle to move the most versatile stem cells from the laboratory to the clinic got another boost with an $8.8 million contract award to the Waisman Clinical Biomanufacturing Facility at the University of Wisconsin-Madison.
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Bone marrow is a leading source of adult stem cells, which are increasingly used for research and therapeutic interventions, but extracting the cells is an arduous and often painful process. Now, researchers have found evidence that fat tissue, known as adipose tissue, may be a promising new source of valuable and easy-to-obtain regenerative cells called hematopoietic stem and progenitor cells, according to a study prepublished online in Blood, the official journal of the American Society of Hematology.
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Even Superman needed to retire to a phone booth for a quick change. But now scientists at the Stanford University School of Medicine have succeeded in the ultimate switch: transforming mouse skin cells in a laboratory dish directly into functional nerve cells with the application of just three genes. The cells make the change without first becoming a pluripotent type of stem cell -- a step long thought to be required for cells to acquire new identities.
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New York Stem Cell Foundation-Druckenmiller Fellow, Daylon James, Ph.D., of Weill Cornell Medial College, is lead author on a study defining conditions for generating a plentiful supply of endothelial (vessel lining) cells that are suitable for therapeutic use. Dr. James and his colleagues created a human embryonic stem cell "reporter" line that can be used to measure endothelial cell production and activity.
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Researchers at the National Institutes of Health and other institutions have discovered the third in a sequence of genes that accounts for previously unexplained forms of osteogenesis imperfecta (OI), a genetic condition that weakens bones, results in frequent fractures and is sometimes fatal.
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