Cloning and Regenerative Medicine News
 | Led by researchers at the University of California, San Diego School of Medicine, scientists have, for the first time, created stem cell-derived, in vitro models of sporadic and hereditary Alzheimer's disease, using induced pluripotent stem cells from patients with the much-dreaded neurodegenerative disorder. ...> Full Article |
Cytori announced the publication of previously reported six-month outcomes from APOLLO, the Company's European clinical trial evaluating adipose-derived stem and regenerative cells (ADRCs) in patients with acute myocardial infarction, as Research Correspondence in the Journal of the American College of Cardiology. The APOLLO trial was a 14-patient, prospective, randomized, double-blind, placebo-controlled, feasibility trial evaluating autologous ADRCs extracted with the proprietary Celution System for the treatment of patients suffering from acute myocardial infarction.
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It is hoped that human embryonic stem cells can be used to generate cell populations with therapeutic utility. In this context, neural derivatives of hESCs are being tested in clinical trials. However, researchers in France have now generated cautionary data that suggest that additional quality controls need to be put in place to ensure that neural derivatives of hESCs are not genomically unstable, a common characteristic of cancer cells.
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The survival of the endangered snow leopard is looking promising thanks to Monash University scientists who have, for the first time, produced embryonic stem-like cells from the tissue of an adult leopard.
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 | Dogs with spinal cord injuries may soon benefit from an experimental drug being tested by researchers at the University of California, San Francisco and Texas A&M College of Veterinary Medicine & Biomedical Sciences -- work that they hope will one day help people with similar injuries. ...> Full Article |
For the first time ever, stem cells from umbilical cords have been converted into other types of cells, which may eventually lead to new treatment options for spinal cord injuries and multiple sclerosis, among other nervous system diseases.
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The grant will allow them to study the impacts of known chemical compounds on adult stem cells, providing the most substantive information to date on how many of the chemicals used every day around the world impact stem cells. The work also will seek to develop a new predictive safety screening tool that manufacturers can use to test the toxicity of new chemical compounds on stem cells. The test will be done without the use of animals and at speeds far faster than current tests.
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 | New research explains how cells regulate their bonds during the development of new blood vessels. For the first time, the role of the protein Raf-1 in determining the strength of the bond between cells has been shown. If Raf-1 is not present, the cells cannot stick together and the formation of new blood vessels is inhibited. This discovery may one day lead to new approaches to cancer treatment. ...> Full Article |
The University of Kentucky will be the first site in the state and one of a select few in the entire country participating in the first stages of a groundbreaking study to investigate the effects of MultiStem, a human adult stem cell product, on patients with acute ischemic stroke.
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Researchers have identified key molecular mechanisms by which implanted human neural stem cells aid recovery from traumatic axonal injury.
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Type 1 diabetes is caused by the body's own immune system attacking its pancreatic islet beta cells and requires daily injections of insulin to regulate the patient's blood glucose levels. A new method described in BioMed Central's open access journal BMC Medicine uses stem cells from cord blood to re-educate a diabetic's own T cells and consequently restart pancreatic function reducing the need for insulin.
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 | A tiny, freshwater flatworm found in ponds and rivers around the world that has long intrigued scientists for its remarkable ability to regenerate has now added a new wrinkle to biology. ...> Full Article |
 | In a major shake-up of scientists' understanding of what determines the fate of cells, researchers at the Walter and Eliza Hall Institute have shown that cells have some control over their own destiny. ...> Full Article |
Researchers have produced the world's first chimeric monkeys. The bodies of these monkeys are composed of a mixture of cells representing as many as six distinct genomes. The advance holds great potential for future research as chimeric animals had been largely restricted to mice. The report, published online ahead of the release of the Jan. 20 issue of Cell, also suggests there may be limits to the use of cultured embryonic stem cells.
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In the future, patients in need of perfectly matched neural stem cells may not need to look any further than their own eyes. Researchers reporting in the January issue of Cell Stem Cell, a Cell Press publication, have identified adult stem cells of the central nervous system in a single layer of cells at the back of the eye.
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