Organ and Tissue Cloning
A $10.2 million commitment from the Robertson Foundation to create a state-of-the-art Translational Cell Therapy Center will advance Duke Medicine's pioneering cell therapy research and treatment programs for children and adults with cancer, cerebral palsy, stroke and brain injuries suffered at birth.
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 | Scientists and surgeons have led a revolutionary operation to transplant a new trachea into a child and use the child's own stem cells to rebuild the airway in the body. ...> Full Article |
Researchers at Children's Hospital Boston recently discovered that infantile hemangiomas originate from stem cells, and have used these stem cells to better understand this tumor in the laboratory. In the March 18 issue of the New England Journal of Medicine, they show that steroids target hemangioma stem cells specifically, reveal their mechanism of their action and suggest other possible ways to halt and shrink hemangiomas.
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 | University of Chicago scientists have successfully used geometrically patterned surfaces to influence the development of stem cells. The new approach is a departure from that of many stem-cell biologists, who focus instead on uncovering the role of proteins in controlling the fate of stem cells.
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Bone marrow stem cells suspended in X-ray-visible microbubbles dramatically improve the body's ability to build new blood vessels in the upper leg -- providing a potential future treatment for those with peripheral arterial disease or PAD, say researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla.
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The muscle-building abilities of hormones known as insulin-like growth factors (IGFs) are legendary. Just do an online search and you'll find not only scientific papers discussing the effects of IGFs on the cells that give rise to muscle tissue, but also scores of ads touting the purported benefits of IGF supplements for bodybuilding.
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The absence of a single gene, called p21, confers a healing potential in mice long thought to be reserved only for creatures like flatworms, sponges, and some species of salamander: regeneration. Researchers from The Wistar Institute demonstrate that mice that lack the gene can regenerate lost or damaged tissue, suggesting that such an ability may be granted to mammals by blocking the effects of p21.
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Each cusp of our teeth is regulated by genes which carefully control the development. A similar genetic puzzle also regulates the differentiation of our other organs and of all living organisms. A team of researchers at the Institute of Biotechnology of the University of Helsinki has developed a computer model reproducing population-level variation in complex structures like teeth and organs. The research takes a step towards the growing of correctly shaped teeth and other organs.
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Northwestern University researchers are the first to fully characterize a special type of stem cell, endothelial progenitor cells (EPCs) that exist in circulating blood, to see if they can behave as endothelial cells in the body when cultured on a bioengineered surface.
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What regenerative medicine therapies are being applied to patients today? What hurdles stand between stem cell therapies and real treatments in the clinic? Keynote speakers at the upcoming inaugural Translational Regenerative Medicine Forum will discuss these topics as well as provide an update on various national and regional stem cell initiatives. The forum, set for April 6-8 in Winston-Salem, is an annual event to focus on fulfilling the promise of regenerative medicine, including best practices and business models.
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 | Sonic hedgehog is at work in mice limb buds in what is known as the ectoderm, the cell layer that gives rise to skin, researchers discovered. Finding Sonic hedgehog here is akin to discovering that yeast has crept from the batter to the frosting, where it has the surprising effect of limiting how much the cake rises. In this case, instead of causing appendages to grow in mice, Sonic hedgehog prevents digits from developing. ...> Full Article |
A mathematical model developed at Purdue University can predict complex signaling patterns that could help scientists determine how stem cells in an embryo later become specific tissues, knowledge that could be used to understand and treat developmental disorders and some diseases.
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 | A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer. ...> Full Article |
Melissa Knothe Tate, of Case Western Reserve University, and Ulf Knothe, of the Cleveland Clinic, have shown that the stem-cell rich periosteum sheath around bone can be used to mend serious bone loss faster and more simply than bone grafts. The pair has developed an artificial periosteum that can be implanted in patients who have too little of the natural covering left.
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 | Scientists at the Stanford University School of Medicine have devised a software algorithm that could enable a common laboratory device to virtually separate a whole-blood sample into its different cell types and detect medically important gene-activity changes specific to any one of those cell types. ...> Full Article |
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