Human kidney cloned in rats (2/22/2005)
Researchers in Japan claim they've cloned a human kidney by harvesting human stem cells taken from adult bone marrow into rat embryos.
The development is expected to encourage regenerative medical specialists to continue research into complex organ cloning
that could one day replace organ donors all together.
The research, headed by Takashi Yokoo, removed rat embryos from the uterus
and implanted human stem cells. They then treated the emrbryo with neutrophic factor genes to help the organ
development.
Two days after the stem cell implantation, the scientists extracted the kidney area from the embryos.
After incubating it for six days, they discovered the development of nephrons, or an excretory unit of the kidney, and the surrounding interstitium.
The researchers later confirmed that the kidneys could be transplanted into a host and grown. The host rat
grew the kidney to approximately 150 milligrams in two weeks. The researchers also confirmed that the kidney functioned
correctly and created urine.
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