All Articles Tagged As: rejection
 | Scientists at the Stanford University School of Medicine have devised a software algorithm that could enable a common laboratory device to virtually separate a whole-blood sample into its different cell types and detect medically important gene-activity changes specific to any one of those cell types. ...> Full Article |
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics. When the gene, called UGT2B17, is missing from the donor's genome but present in the recipient's, transplants have a significantly greater risk of a serious side-effect known as graft-versus-host disease, in which immune cells from the donor attack tissues in the recipient.
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Before T cells are sent into battle, these sentinels of the immune system must complete a rigorous educational process. There are basically two things a T cell must demonstrate before it makes the grade. It must recognize specific molecules on the surface of foreign cells. And it must refrain from attacking the body's own healthy cells.
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Dutch researchers Jeroen van den Beucken and John Jansen have given body implants a DNA layer. This layer ensures a better attachment, more rapid recovery of the surrounding tissue and less immune responses. The older we get the more 'reserve-parts' we need. Up until now placing such parts yielded advantages, but also disadvantages such as inflammations and immune responses. Van den Beucken's invention makes it easier and more reliable to use implants and has already been patented.
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A University of Michigan Health System study is important step on path to reducing transplant rejection rates.
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