All Articles Tagged As: pluripotency

New $8.9 million project aims to unlock stem cell secrets (8/5/2008)

NIGMS grant funds University of Wisconsin-Madison for five years, to study pluripotency. ...> Full Article

Scientists Discover Synthetic Chemicals that Create Pluripotent Stem Cells from Adult Cells (6/19/2008)

Scientists report that they have significantly improved upon a revolutionary technique that uses genes to turn skin cells from an adult back into pluripotent stem cells. ...> Full Article

Wealth of genomic hotspots discovered in embryonic stem cells (6/15/2008)

Should advance understanding of cell reprogramming, renewal and pluripotency ...> Full Article

Scientists identify role of tiny RNAs in controlling stem cell fate (3/7/2008)

Understanding these key regulatory factors is critical for potential therapeutic use of stem cells ...> Full Article

Molecular alliance that sustains embryonic stem cell state (3/5/2008)

Allied proteins known as transcription factors ...> Full Article

NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness (3/4/2008)

Linkage of pluripotent stem cell-associated transcripts to regulatory gene networks ...> Full Article

Major step forward in understanding cell reprogramming (2/15/2008)

Researchers define sequence of events during reprogramming process ...> Full Article

Reprogrammed adult cells treat sickle-cell anemia in mice (12/11/2007)

Mice with a human sickle-cell anemia disease trait have been treated successfully in a process that begins by directly reprogramming their own cells to an embryonic-stem-cell-like state, without the use of eggs. This is the first proof-of-principle of therapeutic application in mice of directly reprogrammed "induced pluripotent stem" (IPS) cells, which recently have been derived in mice as well as humans. ...> Full Article

Yamanaka Reports Additional Success in Reprogramming Human Adult Cells into Embryonic-like Stem Cells (12/1/2007)

Building on their research reported last week, acclaimed stem cell researcher Shinya Yamanaka, MD, PhD, senior investigator at the UCSF-affiliated Gladstone Institute of Cardiovascular Disease (GICD), and colleagues have shown how to convert adult mouse or human skin cells into cells that resemble embryonic stem cells without using the tumour-causing gene c-Myc. The paper will be published online in Nature Biotechnology. Elimination of c-Myc is considered a critical step in making these so-called "reprogrammed" cells safe for clinical applications in patients. ...> Full Article

Adult stem cells lack key regulator (10/24/2007)

The protein Oct4 plays a major role in embryonic stem cells, acting as a master regulator of the genes that keep the cells in an undifferentiated state. Unsurprisingly, researchers studying adult stem cells have long suspected that Oct4 also is critical in allowing these cells to remain undifferentiated. Indeed, more than 50 studies have reported finding Oct4 activity in adult stem cells. ...> Full Article