All Articles Tagged As: pancreas
A study to be published today in the leading international journal Cell Metabolism describes how a research group led by Dr. Robert Screaton, who holds the Canada Research Chair in Apoptotic Signaling at the University of Ottawa, used sophisticated genetic engineering to remove or "knock out" the Lkb1 gene from beta cells of laboratory mice. The result was an increase in both the size and number of beta cells, as well as greater amounts of insulin stored and released by the cells.
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Research provides important insight into possible regenerative
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The Nobel laureate Mario Capecchi has worked with a researcher from the Catholic University of Rome to mark and isolate stem cells from tissues. In the pancreas, surprisingly, the two scientists discovered that these cells are very active. The article has been published in PNAS.
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Two review articles examining the best sites for islet cell transplantation, value of porcine islet cells, and engineering of a bioartificial pancreas demonstrate that problems of poor engraftment and immune recognition can be better prevented, making islet transplantation more feasible. Findings suggest the pancreas remains the best site for islet transplantation; porcine islet cells for transplant can be obtained in quantity and easily proliferate; and a newly fabricated prevascularized bioartificial pancreas can increase blood flow.
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Scientists have discovered a new technique for turning embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant breakthrough in the quest to find new treatments for diabetes
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