All Articles Tagged As: alzheimers
Targeted immune suppression using human umbilical cord blood cells may improve the pathology associated with Alzheimer's disease
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Results of a new study indicate a strong link between the loss of the neuronal receptor LR11 and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease.
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High stress levels may contribute to memory loss among people at risk for developing Alzheimer's disease. The A4 variant of the apolipoprotein E (APOE) gene contributes to the risk for memory loss related to Alzheimer's disease. Similarly, high circulating levels of cortisol, associated with high stress levels, also impairs memory. However, the interactive effects of this risk genotype and chronic stress are not well understood, so a new study being published in the September 1st issue of Biological Psychiatry was designed to explore this relationship.
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 | Genetically engineered cells implanted in mice have cleared away toxic plaques associated with Alzheimer's disease. ...> Full Article |
Scientists working on a cure for Alzheimer's disease find it hard to develop drugs that will pass through the highly selective blood-brain barrier. That may be why a Tel Aviv University researcher decided to take an alternate route - through the nose.
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 | Despite the rapid rise of Alzheimer's disease - the Alzheimer's Association predicts as many as 7.7 million cases by 2030 - there are no preventative treatments available, few in the pharmaceutical pipeline, and those drugs being developed all share the same two molecular targets. Now Rockefeller University researchers report that by targeting a different molecule, a blood-clotting protein called fibrin, they could reduce inflammation in the brains of mice with different models of the disease. ...> Full Article |
Nerve cells must perform millions of neuronal processes and form connections between them during embryonic development to ensure that the nervous system will function properly. Dr. Marta Rosário and Prof. Walter Birchmeier from the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch (Germany), a member of the Helmholtz-Association of National Research Centres, have discovered a novel regulator which is crucial for this process and which they named NOMA-GAP (Neurite-Outgrowth MultiAdaptor RhoGAP).
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Scientists are trying a plumber's approach to rid the brain of the amyloid buildup that plagues Alzheimer's patients: Simply drain the toxic protein away.
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 | A team of scientists led by professor Kiminobu Sugaya at the University of Central Florida may have found a new way to treat Alzheimer's disease. ...> Full Article |
 | New insights into how bacteria form fibers called curli offer intriguing clues to the formation of harmful protein tangles in diseases such as Alzheimer's, Huntington's and Parkinson's, University of Michigan researchers report. Their results will be published online in the Proceedings of the National Academy of Sciences during the week of July 9-13. ...> Full Article |
A recent study in Journal of Neuroimaging suggests that cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease. Older adults showing signs of both conditions were seven-times more likely to develop Alzheimer's than their peers.
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A role for prion proteins, the much debated agents of mad cow disease and vCJD, has been identified. It appears that the normal prions produced by the body help to prevent the plaques that build up in the brain to cause Alzheimer's disease. The possible function for the mysterious proteins was discovered by a team of scientists led by Medical Research Council funded scientist Professor Nigel Hooper of the University of Leeds.
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Four million people in the United States and 15 to 20 million people worldwide are affected by Alzheimer's disease. These numbers are likely to triple by 2050 due to the fact that 24 percent of the population will be more than 65 years old. In their attempt to combat the disease, two University of Missouri-Columbia professors have identified new mechanisms that could have major implications in the development of treatments for the disease. The National Institutes of Health recently awarded a $6 million grant to the Mizzou researchers to continue their study.
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Nutritionists have long endorsed fish as part of a heart-healthy diet, and recent studies have suggested that omega-3 fatty acids found in the oil of certain fish, algae and human breast milk may also benefit the brain by lowering the risk of Alzheimer's disease.
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 | The first pigs containing genes responsible for Alzheimer’s disease will be born in Denmark in August. This event is a landmark achivement in the effort towards finding a cure for the disease. ...> Full Article |
 | Seven years ago, Jordan Tang, Ph.D., led a team of scientists at the Oklahoma Medical Research Foundation that identified and cloned the enzyme believed to cause Alzheimer's disease, then created an inhibitor to halt the enzyme's action. Today, a biopharmaceutical company announced that it has begun human clinical trials of an Alzheimer's drug based on Tang's discoveries. ...> Full Article |
Researchers from the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND) have discovered how the death of brain cells caused by a stroke or head injury may cause generation of amyloid-beta protein - the key component of senile plaques seen in the brains of patients with Alzheimer's disease. Their report appears in the June 7 issue of the journal Neuron.
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Powerful research tools and public data set opens new era in the genetic study of Alzheimer's
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Four million people in the United States and 15 to 20 million people worldwide are affected by Alzheimer's disease. These numbers are likely to triple by 2050 due to the fact that 24 percent of the population will be more than 65 years old. In their attempt to combat the disease, two University of Missouri-Columbia professors have identified new mechanisms that could have major implications in the development of treatments for the disease. The National Institutes of Health recently awarded a $6 million grant to the Mizzou researchers to continue their study.
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New findings fit well with vaccine approach to fight disease
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 | A molecule designed by a Purdue University researcher could lead to the first drug treatment for Alzheimer's disease. ...> Full Article |
Magnetic resonance imaging (MRI) that shows patterns of brain tissue loss may help physicians predict which patients with amnestic mild cognitive impairment (early Alzheimer's disease) will develop full-blown Alzheimer's, according to findings of a Mayo Clinic study presented in Boston today at the annual meeting of the American Academy of Neurology.
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