Teeth grown in lab transplanted into mice (3/1/2007)
Researchers in Japan have successfully grown mice teeth in their laboratory and transplanted them into living mice.
The process is described in a paper titled "The development of a bioengineered organ germ method" in the journal Nature Methods by Dr. Takashi Tsuji and other researchers with the Department of Biological Science and Technology at the Tokyo University of Science.
Though teeth have been grown in pigs and mice before, this is the first time someone has grown them "in vitro", or outside a living organism. This has been considered a major hurdle to growing teeth for replacements in humans, because the teeth can take several weeks to fully mature, and can't be compressed until completely grown and seated in the jaw.
The process works by taking epithelial and mesenchymal tissue from an existing tooth. Both types of tissues are then refined to become stem cells, which have the ability to become connective tissue, blood vessels, and the outer surfaces of the tooth. The refinement process takes 2 days for enough cells to be grown.
The epithelial and mesenchymal stem cells are then allowed to grow until a high cell density is achieved, which forces them to become the correct type of teeth. After two weeks, the cells have become fully grown teeth, and can be implanted into a mouse.
Transplantation is then achieved by cutting a small hole in the jaw where the tooth is to be implanted. The tooth is then implanted and the area thoroughly cleaned. Two more weeks after transplantation, the teeth are seated in the jaw, and have all the qualities of an original tooth, including: blood vessels, periodontal ligaments, alveolar bone, root, enamel and dental pulp.
This groundbreaking research takes us one step closer to testing on humans.
Other researchers involved in the study include:
- Kazuhisa Nakao
- Ritsuko Morita
- Yasumitsu Saji
- Kentaro Ishida
- Yusuke Tomita
- Miho Ogawa
- Masahiro Saitoh
- Yasuhiro Tomooka
- Takashi Tsuji
Comments:
| 1. |
Bob Mar |
11/9/2007 8:07:28 PM MST |
Hurry up!
I need new teeth, I'm a handsome man but I'm afraid to smile.
|
| 2. |
Anthony Whalen |
4/20/2008 6:17:04 PM MST |
Why is this kind of work not on the radar screen? If you search on clone teeth you get practically nothing. I guess the research is very hush hush because people are worried about patents. Also, the dentists may not be dancing for joy at the prospect of their educations being rendered obsolete. Hurry up you guys!!! |
| 3. |
Monisha |
5/30/2009 10:43:43 PM MST |
you guys can experiment on me, if you say you need a human volunteer. I just lost a molar. I'm 26 and a doctor, by the way! Great work guys, waiting for this to be a practical reality... |
| 4. |
Pamela |
7/9/2009 2:40:06 PM MST |
If you need a volunteer, please contact me first. I have been waiting for this for a long time. Thanks |
| 5. |
kirby |
11/9/2009 7:52:15 PM MST |
Yes, I lost my front teeth in a car accident in 1987, I like many others would love to have human teeth again. but guys if you want this to happen.. you need to make damn sure you take care of your teeth between then and now. Most people don't realize that you lose bone when you lose a tooth. Denture patients lose bone constantly making dentures harder and harder to stay in over their lifetime. If you don't have good bone support. you can't have implants and if you don't have good bone support, I would imagine you would not be chosen for the clone implant. I know this because I make dentures for a living. I would like nothing more than to never make one again but this will take a lot of years to come to fruition and be very expensive. K. |
| 6. |
dana |
4/8/2010 2:25:16 PM MST |
I am a survivor of a abusive relationship in turn before leaven him he busted out all my front top teeth.. With no insurance and as a single mom then on my on to fight divorce and raise my kids by him and therapy to me and them for to deal what he had done to all us was not able to have them fix and years later you know what happen to teeth around them I would love to have my pretty smile back. I am not just tormented of mental and physical abuse he did I am reminded every time I look in the mirror of it |
| 7. |
Dana |
4/8/2010 2:26:32 PM MST |
Note to above another slap in face is he only got 9 months probation for it |
| 8. |
JM |
4/28/2010 10:34:49 PM MST |
To the above - currently you can receive titanium implants. Crowns are placed over them, and they look pretty realistic. Downside of course is the cost. I'm sure cost would be an issue with this as well.
@Anthony Whalen - While it is true that you could replace teeth you lose due to just not taking care of them with this method, there are other issues to be concerned with. Dentists and dental hygienists are unappreciated mostly because the research just hasn't been seen much. Not providing yourself with proper home-care leads to the formation of plaque which causes inflammation. Inflammation of any kind has been linked to issues such as diabetes, heart problems, kidney problems, low birth-weights (even still birth, bacteria found in the mother's mouth was also found in the baby). While it is fantastic to have real teeth in place of implants or dentures, it is still a very major and unrealized part of your health to maintain good oral hygiene.
@Dana - I'm very sorry to hear your story. I wish you and your children the best. Just remember that every time you look in the mirror that's also someone who was smart enough to get away from such a toxic relationship.
|
| 9. |
Anoosha |
6/26/2010 8:38:45 AM MST |
Wow getting closer & closer to the ultimum magic of 21st century!!
please please hurry up!!!
I've been in and out of the dentists' offices since I can remember!!
Had my first cap when I was only 9!
Have spent a fortune on my teeth and they're still not perfect!
Please put it on fast track before I have to wear dentures!! :-))
|
| 10. |
Algert Kalica |
8/28/2011 12:26:23 PM MST |
Hey, if more volunteers are needed, do not hesitate to contact me! |
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