Cloned Knee Cartilage (7/5/2006)
Scientists led by Antony Hollander, ARC Professor of Rheumatology & Tissue Engineering at Bristol University
in South West England have successfully grown and implanted knee cartilage
into 23 patients. The process started by removing health cartilage from 23 patients. The cartilage is then
grown for 14 days in a culture. The researchers then deposited the cartilage cells onto a esterified hyaluronic acid
scaffold. They were grown on the scaffold for another 14 days.
After growing on the scaffold the cartilage was implanted into the study patients. Cartilage regeneration occured
in 10 of th 23 patients, including patients with early osteoarthritis. Fully recovered cartilage was evident as early
as 11 months after the operation.
This is good news for athletes with knee injuries, as left untreated most cartilage injuries will progress
to osteoarthritis. Over 20 million people in the United States suffer from osteoarthritis, which is a disease
of the joints that can cause severe pain in the affected joints. Until now, the only effective treatment was
total knee replacement.
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