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Growing new teeth (2/17/2004)

Tags:
teeth, stem cells, tissue engineering

Professor Paul Sharpe, who is the director of the craniofacial department at the Dental Institue in King's College London says researchers can grow fully formed adult teeth in mice. The technique, similar to those used by Forsyth Institute researchers, uses the subjects own dental stem cells. The stem cells are then combined with embryonic epithelium, and are placed into the kidneys of the mice, which provide a good supply of blood and oxygen for the tooth to develop. The tooth is then removed from the kidney and is transplanted into the mouth. The tooth, which is still small, then grows into a normal tooth attaching to the underlying bone.

The only major hurdle is that the researchers haven't determined how to control which type of tooth will be grown. It is only after the tooth is attached in the mouth, that it starts to take form. Sharpe is convinced this will be solved and within a couple years he'll start testing on human patients.

Sharpe founded a start-up company, Odontis, in 2002 to bring the technique to market. Odontis holds all the patents for using stem cells to grow teeth.

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Comments:

1. antonia baars

1/24/2007 6:04:57 AM MST

Hi, i am female 53 years old and i have big problems wit my fals teeth,wich is not a suprise i have them for over 30 years now and i saw your article about mouse teeth growing,im curious how far you are with your technique to bring it on the market,i would love to have the chance of new teeth so i guess i wanna be one of the first too try.

kind regards
Antonia baars


2. Nellie Pennella

10/21/2007 8:22:45 PM MST

I am interested in the developing of new teeth and how close you are to trying this technology in humans. I also would like to know if this can be done if a person already has an implant or if all their teeth have been removed?
Thank you kindly.
Nellie Pennella


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