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Advances in growing new teeth (1/16/2007)

Tags:
teeth, stem cells, tissue engineering

Dr. Paul Sharpe, through his startup Odontis, has continued his research into growing teeth from dental stem cells and has learned to control the type of tooth formed.

In a previous article about Dr. Sharpe’s work in growing new teeth, he was unable to control the type of tooth formed. Now he claims he can control the basic shapes, i.e. molar & incisor. In his studies on mice, it takes about 8 weeks to grow a tooth.

The teeth are grown in mice kidney capsules because they provide a convenient site for prolonged growth due to the bountiful blood supply to the developing tooth.

Dr. Sharpe’s aim was never to grow teeth in kidneys. This is just his experimental test system. Dr. Sharpe notes that others are working on creating bio-reactors, from which organs and tissues can be grown, but wouldn’t comment on whether his goal was to produce a similar device.

Implanting teeth into the jaw of a mouse is quite a tricky micro-surgery. The tooth bud is implanted in the jaw and the gum stitched or sealed with a clinical "glue". Though they haven't started human clinical trials yet they expect the procedure to be less invasive than, say, a tooth extraction and the requirements for post-procedure care would be similar.

After implantation it takes the tooth about 3 weeks to set in the jaw of a mouse. As long as the tooth isn’t under heavy load, it sets well.

If Dr. Sharpe’s patented technique can be adapted for use in humans, and there are no ill-effects, he and his company may become one of the largest biotech company’s on earth. Dr. Sharpe hopes to begin human trials in 4 years if all goes well.

Odontis has received over $2 million of funding to date from a combination of the university seed fund, the Wellcome Trust, Nesta and an undisclosed business angel investor. He has tried to obtain funding from venture capitalists, but claims “VC's wont touch this since it is to far from the market”.

Comments:

1. Betty Boyette

1/29/2007 10:06:47 PM MST

wish it was now


2. Susan Aron

2/7/2007 7:41:39 AM MST

I can only hope that this becomes available soon. I have long dreamt of having a second chance at having a mouthful of cavity-free teeth.


3. diana oleary

2/11/2007 12:54:13 PM MST

I had a recent accident and broke my entire jaw. My jaw is wired and what is left of my teeth are loose in the sockets. Between the accidents of the young, and the horrors of the teeth situation in the US, this really needs more than 2 million in investment!!! How can we help this funding grow? Please let me know how to cause this company to grow. I don't know why God only gave us 2 sets of teeth, but he must have known technology would become the next answer we were evolving into. In other words God must have wanted us to handle the issue this way, and the time is now.

Thank You,
isisisencia@yahoo.com, ouivalerie@yahoo.com


4. healthman@gmail.com

2/12/2007 8:51:28 AM MST

A cousin of mine suffered some brain damage in a car accident several years ago. He has short term memory. Every morning his sister calls to make sure he reads it or tell him anything that he forgot. WBR LeoP


5. nada mohamed

3/10/2007 3:32:33 PM MST

i had an accident when i was 13 and since then i suffer from my teeth i cant close my mouth properly i have tried to commitsuicide its too bad i cant bare my mouth i wanna be the first to try cloning i am desperate consider me a pig!please help


6. Sohiab Rehman

3/22/2007 5:24:49 AM MST

Good Luck Mr Sharp. I had little dental surgery when I was younger and no I have missing teeth and am waiting for the day I lose the rest of my teeth. Hopefully he'll solve this problem in the next 10 years!


7. peter

3/27/2007 10:01:32 PM MST

Don't fret, the answers are coming. Have Faith.

Regards,
Peter


8. ang

4/19/2007 11:21:32 AM MST

Will this really become a reality because everything it seems has a potential cure or fix on the horizon but it never happens.


9. chris

7/23/2007 5:04:41 AM MST

is this even close to begin a reality there are so many of us that need new teeth that test subjects are ready and waiting anytime these dentist are ready to try on humans me included i still have my teeth but the ground down to almost nothing so it looks like i don't have any teeth at all smiling is some thing i've not done in public for so long with out covering my mouth fist wish this was now and not later


10. Fernando

10/3/2007 8:23:27 PM MST

I hope to have this technology available soon. I have lost three pieces (one because of an infection and two because of orthodontics) but they remain in my mouth as only the nerves were affected. The nerves had to be removed... and it's quite desperating, I'm only 22 but I already now that as they don't have nerves, they don't have the whole conduct that provide calcium and everything... well they will turn fragile and they will change its color. All that I can say is good luck! And please keep this efforts ahead! There has to be a lot of people like me.


11. Zero

11/5/2007 6:45:11 PM MST

I wish for another chance to brush my teeth and keep it clean


12. Hemaster

11/10/2007 1:18:59 AM MST

I have screwed up by not brushing my teeth daily and I hope this technology would give me another chance.


13. Dana

11/20/2007 8:26:54 PM MST

Today there a breakthrough was announced in stem cell research. I hope this paves the way for better and quicker results.


14. Erlina

11/27/2007 1:20:11 PM MST

Dr. Mr Paul Sharpe,
My name is Erlina Vicente, and I have been following your research on the development of new teeth from stem cells. I was wondering if I might be of some help as a volunteer to test your theory or expand on it.

I have lost my front tooth, however it can be said that I do have a spare front tooth that has failed to grow out and has remained inside my gums. My thoughts were you might be able to extract my tooth and use its cells as parts to hopefully grow another in the place where I am missing a tooth.

If anything I would also appreciate any other information you might have on this topic, perhaps other countries or researchers that have been experimenting on the growing new teeth.

Thank you,
Erlina



15. Dana

11/29/2007 8:38:02 PM MST

I would like to point out that it might take at least 10-15 years before this technology becomes available to the general public. There is also the factor of being able to afford it. I'm not trying to discourage anyone but you need to be realistic about the possibilities. Right now we can do two things (be patient and pray for a miracle). If you ask me I think Paul Sharpe was too eager to announce the possibility of re-growing teeth but not eager enough to keep the consumers up date.


16. Carla

12/6/2007 12:19:05 AM MST

15 years? Are you quoting a source? It could be sooner than that. Carla you have no idea when this technology will become available.


17. Dana

12/9/2007 7:50:54 PM MST

Carla, every article that I have read listed that it would take 10-15 years before stem cells could become main stream. you can check Prof. Paul Sharpe's website. The information is not dated so one does not know when the information was posted. Here is one source.
http://www.futurepundit.com/archives/000167.html


18. Michael Chassé

2/24/2008 6:35:01 PM MST

I'm not sure but the article but the article seemed to have been in 2002 (the one that says that this technology will be available in 10 years from now...)


19. Martin Camire

4/23/2008 10:25:40 PM MST

Hello Dr. Sharpe, I am 45 years old and am now getting my third set of dentures tomorrow. I have full dentures and a shrinking gum ridge. I was looking into implants and found news of your research. I am excited about your work, and would consider being a test subject for human testing. Please respond if you are interested. Thank You
Martin Camire


20. Derek

4/29/2008 8:51:19 PM MST

Helo Dr Sharpe,I have been looking for something like this for awhile, sitting here thinking why can't they find a way to grow a third tooth i decided to punch that in with stem cells andd found this,I actually have a bridge for a front tooth which , im now having huge health problems including electrical sensitivities , when the front bridge has come out accidently i felt great in the two weeks it was out seemed like my immune system was picking up only to have it come right back down the day the bridge got put back in, so now im convinced its at least contributing to my health issues but i cant go around without a front tooth , i would love to be considered for a volunteer for this pleae e mail me at lilbull624@aol.com if any info comes
Thanks !!


21. deanna

5/26/2008 4:22:28 PM MST

Hello Dr Sharpe,

I have had numerous root canals in my molars that now, at age 41 have gone bad. 2 of the teeth I had pulled and the other 4 have crowns, but my dentist says my real teeth are shrinking below the gumline and may also have to be pulled. I would definitely like to be a guinea pig for this new procedure because I figure it can't get any worse than having the other 4 molars that I have left get pulled out. I do not want to put false teeth or bridges as I know there are complications with them. If interested, contact me.


22. Frank Lucero

8/25/2008 4:16:02 PM MST

I have eliminated all diseases of the body except for my teeth. I am over 70 and am working on reversing the aging process (UCSD). I am now shooting for a vibrant age to at least 140. I am looking for information on growing a new set of Teeth... Frank@ahso.info


23. aj

10/9/2008 1:29:08 PM MST

hello dr Sharpe,
i am an 18 yr girl livin in india......i had an accident when i was 7 and ma front tooth got chipped.....around 2 yrz bck ma dentist said dat the tooth did nt form a proper root and hence extracted it and replaced it with a bridge.....since u knw dat our country iz nt very advanced in technology the job done looks pathetic.....people keep questioning me about ma teeth..asking if i have fake teeth..they laugh n make fun of me...m quite pretty..but these teeth make me luk pathetic..i cry practically every night.....m so fed up of my life....please doctor....help me....i d love to be the one you can experiment on...please do contact me..m waiting eagerly...ma college life iz practically ruined due to this problem.....please doctor.....


24. gavulla ravinder reddy

10/15/2008 1:05:34 AM MST

please give the latest information on the development of odontis


25. steve

10/22/2008 5:54:48 PM MST

CURRENT STATUS:

We receive many enquiries from people who wish to volunteer for clinical trials of the BioToothTM or are seeking advice on potential treatment options. The BioToothTM technology is still under development and it will be several years before we are in a position to start initial clinical trials in humans. We are therefore not seeking volunteers for clinical trials at this stage and are not holding a waiting list of volunteers.

Any further information will be posted on this website.

In other words it'll never see the light of day.


26. steve

10/22/2008 6:01:18 PM MST

http://www.odontis.co.uk/status.php


27. Rafael Bauza

11/30/2008 2:02:14 AM MST

I just lost 2 teeth in a fight and I wish this was available now.


28. Randy Williams

1/5/2009 12:24:30 PM MST

I've had all my original teeth removed in July 2001. I have NO teeth and believe that I would be perfectly suitable for a clinical trial for stem cell regrowth. Can somebody send me information on any clinical trials available. I'm 43 years old.


29. alex

3/13/2009 5:35:27 AM MST

I'm very optimistic about this and personally i cant wait for all the Fluoride and Mercury pushers we call dentist loose their jobs ...
when they do I'll play that bob dylan song... how does it feel?

think about it this breakthrough could make braces and things think invisigline obsolete ..

given that if your teeth are really ugly
would you rather have a mouth full of metal or just get them all cloned..
but pulled out first

yikes!
food for thought


30. Brian

5/29/2009 1:32:42 PM MST

This is awesome Where do i sign up for a test subject? my teeth have and do suck and every dentist i see wants tons of $$$ to give me fake ones....i'll put it on the line to be a test subject for this if i get new teeth!


31. jessica

8/5/2009 11:24:16 PM MST

I HAD A DISEASE THAT CAUSED ME TO HAVE ALL OF MY TEETH EXTRACTED AT A YOUNG AGE. I WOULD LOVE A CHANCE TO HAVE GOOD HEALTHY REAL TEETH AGAIN, SIGN ME UP FOR ANY TESTING


32. Cindy

1/19/2010 2:17:37 PM MST

My boyfriend is 46 years old and is growing in it appears to be 5 new bottom molars. This is astonishing and I hoped you could help us understand this. Studying him may be useful without stem cell research. He would be available for further study. Please reply.

Cindy


33. She Bee

2/15/2010 7:49:46 AM MST

I would love to be first in line on this project, believe me! I have missing teeth and would love to be able to grow new ones of my own. (Dear Lord, please let it happen?) But, there is another thing that comes to mind for me, only because I suffer this problem. I have receded gum line inbetween my front big tooth and the canine tooth on the right side of my mouth. The bone has obviously deteriorated on that side. Will this issue be addressed while learning how to grow the real teeth?
I'd really love to know this beacause this is all part of the mouth! :-) Thank you.


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